Atopic Dermatitis Inhibitory Effect of Chondria crassicaulis Ethanol Extract

This study investigated the effect of Chondria crassicaulis ethanol extract on degranulation rat basophilic leukemia-2H3 cells and 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in Bagg Albino/c mice. General properties (proximate analysis, total phenol flavonoid) were measured; moreover, beta-hexosaminidase release cytotoxicity cells, severity dermatitis, production cytokines, immunoglobulin E content an mouse model estimated. decreased secretion without serum. In addition, interleukin-4 interleukin-5 splenocytes, whereas significantly increased level interferon gamma. Furthermore, alleviated induced by dermatitis causing toxicity to splenocytes. Therefore, present findings suggest that can relieve regulating activity type 1 T helper 2 mediate cellular immune response it be used as effective alternative therapy for dermatitis.